Impact of pre-transplant induction therapy on outcomes of patients who undergo autologous stem cell transplantation for mantle cell lymphoma in first complete remission

Authors

Omar Albanyan, Department of Oncology, Karmanos Cancer Institute/Wayne State University, Detroit, MI, USAFollow
Samer Alkassis, Department of Internal Medicine, Wayne State University, Detroit, MI, USA
Seongho Kim, Biostatistics Core, Department of Oncology, Karmanos Cancer Institute/Wayne State University, Detroit, MI, USA
Andrew Kin, Department of Oncology, Blood and Marrow Stem Cell Transplant Program, Karmanos Cancer Institute/Wayne State University, Detroit, MI, USA
Asif Alavi, Department of Oncology, Blood and Marrow Stem Cell Transplant Program, Karmanos Cancer Institute/Wayne State University, Detroit, MI, USA
Lois Ayash, Department of Oncology, Blood and Marrow Stem Cell Transplant Program, Karmanos Cancer Institute/Wayne State University, Detroit, MI, USA
Voravit Ratanatharathorn, Department of Oncology, Blood and Marrow Stem Cell Transplant Program, Karmanos Cancer Institute/Wayne State University, Detroit, MI, USA
Dipenkumar Modi, Department of Oncology, Blood and Marrow Stem Cell Transplant Program, Karmanos Cancer Institute/Wayne State University, Detroit, MI, USA
Joseph P. Uberti, Department of Oncology, Blood and Marrow Stem Cell Transplant Program, Karmanos Cancer Institute/Wayne State University, Detroit, MI, USA
Abhinav Deol, Department of Oncology, Blood and Marrow Stem Cell Transplant Program, Karmanos Cancer Institute/Wayne State University, Detroit, MI, USA

Abstract

Mantle cell lymphoma is a rare subtype of non-Hodgkin’s lymphoma with poor prognosis and continue to be challenging to treat. The choice of first line induction regimen remains a topic of debate due paucity of clinical trials. We retrospectively evaluated 66 patients diagnosed with mantle cell lymphoma who achieved first complete response after induction chemotherapy followed by autologous stem cell transplant. Treatment groups were divided into lowintensity versus high-intensity regimens. Our data showed the intensity of induction regimen does not impact posttransplant outcomes of mantle cell lymphoma who underwent autologous stem cell transplant in first complete response.

Recommended Citation

Albanyan, Omar; Alkassis, Samer; Kim, Seongho; Kin, Andrew; Alavi, Asif; Ayash, Lois; Ratanatharathorn, Voravit; Modi, Dipenkumar; Uberti, Joseph P.; and Deol, Abhinav (2023) "Impact of pre-transplant induction therapy on outcomes of patients who undergo autologous stem cell transplantation for mantle cell lymphoma in first complete remission," Hematology/Oncology and Stem Cell Therapy: Vol. 16 : Iss. 2 , Article 9.
Available at: https://doi.org/10.1016/j.hemonc.2021.07.005

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