Background: Allogeneic hematopoietic stem cell transplantation (allo-HCT) is currently the only curative treatment for patients with chronic lymphocytic leukemia (CLL). Methods: We analyzed the outcomes of 93 patients (median age: 52 years) who underwent allo-HCT at our center between 1989 and 2019. Results: After a median follow-up of 35 months, relapse was observed in 15.1% (n = 14) patients. The estimated 2-year non-relapse mortality, relapse-free survival, and overall survival (OS) were 38.1%, 54.2%, and 58.7%, respectively. The ECOG performance status 2 (hazard ratio [HR]: 4.1; p = .001) and use of total body irradiation (in a myeloablative conditioning regimen; HR: 2.64; p = .005) were predictive of poor OS after multivariable analysis. The occurrence of sinusoidal obstruction syndrome/veno-occlusive disease post-transplant was associated with poor survival (p = .001).
Conclusion: Although the use of kinase and bcl2 inhibitors may result in a decrease in the number and need of transplants, allo-HCT remains a viable option in selected patients with high-risk CLL and good performance status.
Linn, Swe Mar; Nampoothiri, Ram Vasudevan; Chen, Carol; Pasic, Ivan; Al-Shaibani, Zeyad; Lam, Wilson; Law, Arjun Datt; Michelis, Fotios V.; Kim, Dennis D.H.; Gerbitz, Armin; Lipton, Jeffrey; Kumar, Rajat; Mattsson, Jonas; and Viswabandya, Auro
"Outcomes of patients diagnosed with chronic lymphocytic leukemia after allogeneic hematopoietic stem cell transplantation: Results from a tertiary care center,"
Hematology/Oncology and Stem Cell Therapy: Vol. 16
, Article 7.
Available at: https://doi.org/10.1016/j.hemonc.2021.09.008
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