Application of EBMT, MASCC and qSOFA scores to predict complicated febrile neutropenia and mortality in autologous stem cell transplant recipients

Tiago A. Barros, Departamento de Clínica Medica, Faculdade de Medicina, Universidade Federal do Rio de Janeiro, Rio de Janeiro, Brazil
Rony Schaffel, Departamento de Clínica Medica, Faculdade de Medicina, Universidade Federal do Rio de Janeiro, Rio de Janeiro, Brazil
Geraldo S. de Azevedo Neto, Departamento de Clínica Medica, Faculdade de Medicina, Universidade Federal do Rio de Janeiro, Rio de Janeiro, Brazil
Bianca de Lucena Gaio, Departamento de Clínica Medica, Faculdade de Medicina, Universidade Federal do Rio de Janeiro, Rio de Janeiro, Brazil
Arthur T. Batista, Departamento de Clínica Medica, Faculdade de Medicina, Universidade Federal do Rio de Janeiro, Rio de Janeiro, Brazil
Marcia R. Valentim, DASA-Complexo Hospitalar de Niteroi, Niteroi, Brazil
Angelo Maiolino, Departamento de Clínica Medica, Faculdade de Medicina, Universidade Federal do Rio de Janeiro, Rio de Janeiro, Brazil
Marcia Garnica, Departamento de Clínica Medica, Faculdade de Medicina, Universidade Federal do Rio de Janeiro, Rio de Janeiro, BrazilFollow

Abstract

Background and objectives: Three different scores were addressed as predictors of outcomes in autologous stem cell transplant (Auto SCT): one was calculated by pretransplant characteristics (European Society for Blood and Marrow Transplantation [EBMT] risk score), and two were calculated at the onset of febrile neutropenia (Multinational Association for Supportive Care in Cancer [MASCC] and Quick Sequential Organ Failure Assessment [qSOFA]). We considered bloodstream infection (BSI), carbapenem prescription, admission to the intensive care unit (ICU), and mortality as outcomes. Patients: A total of 309 patients with a median age of 54 years were enrolled. Results: Patients with EBMT score ≥4 (EBMT 4þ) had higher ICU rates (14% vs. 4%; p < 0.01) and more carbapenem prescriptions (61% vs. 38%; p < 0.001) than those with EBMT score

Recommended Citation

Barros, Tiago A.; Schaffel, Rony; Azevedo Neto, Geraldo S. de; Lucena Gaio, Bianca de; Batista, Arthur T.; Valentim, Marcia R.; Maiolino, Angelo; and Garnica, Marcia (2022) "Application of EBMT, MASCC and qSOFA scores to predict complicated febrile neutropenia and mortality in autologous stem cell transplant recipients," Hematology/Oncology and Stem Cell Therapy: Vol. 16 : Iss. 4 , Article 12.
Available at: https://doi.org/10.56875/2589-0646.1034