Peritoneal and Pleural Drains in Pediatric Hematopoietic Cell Transplant Recipients With Veno-Occlusive Disease are Safe and do not Adversely Impact Clinical Outcomes

Authors

Hemalatha G. Rangarajan, Division of Pediatric Hematology/Oncology/Bone Marrow Transplant, Nationwide Children’s Hospital, Columbus, Ohio, Department of Pediatrics, The Ohio State University, Columbus, OhioFollow
Vinita B Pai Pharm, College of Pharmacy, The Ohio State University
Joseph R. Stanek, Division of Pediatric Hematology/Oncology/Bone Marrow Transplant, Nationwide Children’s Hospital, Columbus, Ohio, Department of Pediatrics, The Ohio State University, Columbus, Ohio,
Cassandra Rush Pharm, College of Pharmacy, The Ohio State University
Jeffrey Naples, Department of Critical Care Medicine, Nationwide Children's Hospital,
Misti Drope, Division of Pediatric Hematology/Oncology/Bone Marrow Transplant, Nationwide Children’s Hospital, Columbus, Ohio, Department of Pediatrics, The Ohio State University, Columbus, Ohio
Veronika Polishchuk, Division of Pediatric Hematology/Oncology/Bone Marrow Transplant, Nationwide Children’s Hospital, Columbus, Ohio, Department of Pediatrics, The Ohio State University, Columbus, Ohio,
Rolla Abu Arja, Division of Pediatric Hematology/Oncology/Bone Marrow Transplant, Nationwide Children’s Hospital, Columbus, Ohio, Department of Pediatrics, The Ohio State University, Columbus, Ohio
Rajinder PS Bajwa, Division of Pediatric Hematology/Oncology/Bone Marrow Transplant, Nationwide Children’s Hospital, Columbus, Ohio, Department of Pediatrics, The Ohio State University, Columbus, Ohio

Abstract

There is a lack of data on the safety and efficacy of peritoneal drain (PD) and chest tube (CT) in the management of effusions in stem cell transplant recipients with veno-occlusive disease (VOD). In this retrospective pediatric study we compared the clinical outcomes and health resource utilization (HRU) in 32 patients with VOD who had a PD placed (PD+) post HCT with 27 patients who did not (PD-). Nine patients had a CT (7 PD+ and 2 PD-). PD+ patients were more likely than PD- patients to have received myeloablative conditioning (100% vs 85.2%; p=0.04) and have severe or very severe VOD (100% vs 56% p

Recommended Citation

Rangarajan, Hemalatha G.; Pharm, Vinita B Pai; Stanek, Joseph R.; Pharm, Cassandra Rush; Naples, Jeffrey; Drope, Misti; Polishchuk, Veronika; Abu Arja, Rolla; and Bajwa, Rajinder PS (2023) "Peritoneal and Pleural Drains in Pediatric Hematopoietic Cell Transplant Recipients With Veno-Occlusive Disease are Safe and do not Adversely Impact Clinical Outcomes," Hematology/Oncology and Stem Cell Therapy: Vol. 16 : Iss. 4 , Article 14.
Available at: https://doi.org/10.56875/2589-0646.1066

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